TACA-37 亚叶酸钙治疗自闭症
本帖最后由 StarCare 于 2026-5-15 16:58 编辑TACA-37 亚叶酸钙治疗自闭症
Folinic Acid (Leucovorin) for Autism
原文网址：https://tacanow.org/family-resources/folinic-acid-for-autism/
概述
亚叶酸钙（Folinic Acid，又称Leucovorin）是叶酸的活性形式之一，在自闭症治疗中显示出显著效果。本文将讨论亚叶酸钙在自闭症中的应用，特别是脑叶酸缺乏症（CFD）的治疗。
叶酸与亚叶酸钙
叶酸形式：
- 叶酸（Folic Acid）：合成形式，需要转化
- 叶酸（Folate）：天然形式
- 5-MTHF（甲基叶酸）：活性形式
- 亚叶酸钙（Folinic Acid）：另一种活性形式
亚叶酸钙的特点：
- 不需要MTHFR酶转化
- 可以绕过某些代谢障碍
- 可以穿过血脑屏障
- 直接支持大脑叶酸需求
脑叶酸缺乏症（CFD）
什么是CFD：
- 大脑中5-MTHF水平低
- 血液叶酸水平可能正常
- 由叶酸受体抗体引起
CFD症状：
- 发育迟缓
- 语言障碍
- 运动障碍
- 癫痫
- 睡眠问题
- 焦虑
诊断：
- FRAT检测（叶酸受体抗体）
- 腰椎穿刺测脑脊液叶酸
- 临床试验治疗反应
亚叶酸钙的作用机制
绕过叶酸受体：
- 叶酸受体抗体阻断正常叶酸转运
- 亚叶酸钙使用替代转运途径
- 可以到达大脑
支持代谢功能：
- DNA合成
- RNA合成
- 氨基酸代谢
- 神经递质合成
治疗效果
可能改善的领域：
- 语言和沟通
- 社交互动
- 认知功能
- 运动技能
- 睡眠质量
- 情绪稳定
研究证据：
- 研究显示部分自闭症儿童对亚叶酸钙有积极反应
- 叶酸受体抗体阳性者效果更明显
- 需要数周到数月才能看到效果
使用方法
剂量：
- 通常从低剂量开始
- 常见剂量：0.5-2 mg/kg/天
- 根据反应调整
处方形式：
- 需要医生处方
- Leucovorin是处方形式
- 补充剂形式的亚叶酸钙也有
配合其他营养素：
- 甲基B12可能增强效果
- B6支持代谢
- 避免合成叶酸
注意事项
副作用：
- 通常耐受良好
- 可能的初始恶化
- 过度兴奋
- 睡眠问题
监测：
- 观察行为变化
- 定期评估
- 调整剂量
谁可能受益：
- 叶酸受体抗体阳性者
- 对甲基叶酸反应不佳者
- 有CFD症状者
谁可能不适合：
- 对亚叶酸钙过敏者
- 某些代谢疾病患者
检测
FRAT检测：
- 检测叶酸受体抗体
- 阻断抗体
- 结合抗体
- 阳性提示可能需要亚叶酸钙
其他检测：
- 血清叶酸水平
- 同型半胱氨酸
- MTHFR基因检测
结论
亚叶酸钙是自闭症治疗的重要工具，特别是对于有脑叶酸缺乏症的儿童。通过FRAT检测识别可能受益的儿童，进行试验治疗，可以改善语言、认知和行为。与了解叶酸医学的医生合作，确定适当的治疗方案。
Leucovorin is best known for treating cancer patients to protect them against chemotherapy
and methotrexate toxicity. However, in autism, Leucovorin is used to treat low folate levels in the brain.
This is called “Cerebral Folate Deficiency (CFD)” and it happens when there is low folate (vitamin B9) in
the brain but normal folate levels in the blood. You can learn more about Cerebral Folate Deficiency
in this TACA article.
亚叶琶钙最为人熟知的用途是治疗癌症患者，保护他们免受化疗和甲氨蝶叭的毒性作用。然而，在自闭症患者
中，亚叶酸钙也用于治疗脑叶酸水平低 。这种情况被称为“脑叶酸缺乏症 (CFD)”，是指脑叶酸 (维生素 BO) 含
TACA 十多年来一直在谈论亚叶酸钙治疗自闭症!
This article will cover frequently asked questions about Leucovorin.
本文将介绍有关亚叶酸钙的常见问题。
What is Leucovorin? 什么是亚叶酸钙?
Leucovorin is a prescription high-dose calcium folinic acid. It is vitamin B9, but this is NOT the same as
folic acid. *Please note that folic acid is detrimental to those with Cerebral Folate Deficiency because it
blocks folate receptors.*
UHR Si SrneUneS, PRLSCES B9，但与叶酸不同。#请注意，叶酸对脑叶酸缺乏症串者
有书，因为它会阻断叶酸受体。*
Leucovorin comes in 5mg, 10mg, 15mg, and 25mg tablets, which are much higher dose than over-the-
counter supplements. Over-the-counter folinic acid is usually dosed in much smaller micrograms (mcg),
and Leucovorin is dosed in higher dose milligrams (mg). The tablets can be crushed and added to food
for consumption. A bit of applesauce works well. It can also be compounded into a liquid form, but this
will not be covered by insurance.
WH BSS 5 Sra, 10 毫克、15 毫克和 25 毫克的片剂规格，其剂量远高于非处方补充剂。非处方亚叶酸钙的剂
量通常以微克 (mcg) 为单位，而亚叶酸钙的剂量则以毫克 (mg) 为单位。可以将片剂压碎后添加到食物中食用。
加一点苹果次效果会更好。亚叶酸钙也可以配制成液体形式，但这不在保险范围内。
Additionally, since Leucovorin is only available via prescription, its quality is regulated by the FDA.
此外，由于亚叶酸钙只能通过处方获得，其质量受到 FDA 的监管。
In some circumstances, if folate is extremely low in the brain, Leucovorin injections may be prescribed.
在某些情况下，如果大脑中的叶酸含量极低，则可能需要注射亚叶酸钻。
Why is Leucovorin given?
为什么要使用亚叶酸钙?
Individuals with autism may have an autoimmune condition where blocking or binding folate
autoantibodies block folate from getting into the brain, resulting in developmental problems and more.
That is why a folate blood test doesn’t tell you much. Learn more in this IG Reel from Dr Frye.
自闭症囊者可能惠有自身免疫性疾病，这种疾病会阻断或结合叶酸自身抗体，阻止叶酸进入大脑，从而导致发育
问题等。这就是为什么叶酸血液检测并不能提供太多信息。想了解更多信息，请观看弗莱博士的 1G 视频 。
genetics.
此外，可能还有其他原因需要使用亚叶酸钙，例如线粒体功能障碍或遗传因素。
Is there research showing dosage for autism?
ARAMA?
This meta-analysis, which is a review of numerous research studies, was done in 2021. The typical dose
for positive blocking or binding autoantibodies is 0.5 to 2 mg / kg / day, but may go higher depending on
individual needs. Dose is typically split into two doses per day. One in the morning, and another mid-
afternoon.
这项葵萃分析于 2021 年完成，是对众多研究的回顾。阳性阻断或结合自身抗体的典型剂量为 0.5 至 2 毫克/千克/
天，但可根据个人需求增加。剂量通常分为每日两次。一次在早上，另一次在下午。
For example, if your child weighs 100 Ibs, you first convert that to kg. 100 Ibs = 45 kg
例如，如果你的孩子体重 100 磅，你首先将其转换为公斤。100 H = 45 公斤
45 kg x 0.5mg = 22.5 mg (minimum, starting dose)
45 公斤 x 0.5 毫克 = 22.5 毫克 (最低起始剂量)
45 kg x 2mg = 90 mg target dose.
45 公斤 x 2 毫克 = 90 豪克目标剂量。
Print and bring this research to your doctor.
打印此研究报告并将其带给您的医生。
How do | get access to Leucovorin?
我如何获得亚叶酸钙?
Leucovorin needs to be prescribed. A functional medicine doctor (MD, PA, NP, or DO) who can prescribe
medication and is trained in how to treat autism medically, or an open-minded neurologist willing to read
the research, may be able to help. Always bring studies for the doctor's perusal when you would like to
discuss a medication with your doctor.
亚叶屋钙需要处方。一位能够开药目接受过自闭症医学治疗培训的功能医学医生 (医学博士、助理医师、执业护
士或骨科医生) ，或者一位愿意阅读相关研究的开放性神经科医生，或许能够提供帮助。当您想与医生讨论用药
方案时，请务必携带相关研究报告供医生参考。
Is Leucovorin covered by health insurance?
健康保险涵盖亚叶酸钙吗?
Yes, it should be. Check your policy and make sure you have met your deductible for the year.
是的，应该可以。请检查你的保单，确保你已经支付了当年的免赔额。
How do | know if my child needs Leucovorin?
我怎么知道我的孩子是否需要亚叶酸钙?
The only way to know for certain is to do a lumbar puncture (spinal tap) because that can tell you the
level of folate (5MTHF) in the brain. Because this is an invasive test, many doctors will prescribe an
empirical trial of leucovorin to see if your child is a responder.
AREA SERIES) (SSA) ，因为这可以告诉你大脑中的叶酸 (SMTHF) 水平。由于这是一种
侵入性检查，许多医生会建议你烷试使用亚叶琶钙进行经验性治疗，看看你的孩子是否有反应。
Other than that, the only other possible testing is a blood test called a FRAT (Folate Receptor
autoantibodies, this may indicate that the brain is not getting the folate it needs.
除此之外，唯一可能的其他检测是血液检测，称为叶酸受体自身抗体检测 (FRAT )。该检测用于检测血液中阻断或
结合的自身抗体。如果检测结果显示存在自身抗体，则可能表明大脑没有获得所需的叶酸。
The FRAT is a test kit that you have to order and have mailed to you. Once you get it, you fill out the
requisition form and bring it to your doctor to sign off on. Then get the blood drawn and sent to the lab.
The results are sent to your doctor. To learn how to read these test results, please read the book called
“The Folate Fix by Dr Frye.”
FRAT 是一套需要您订购并邮寄的检测试剂盒。收到试剂盒后，您需要填写申请表并交给医生签字。然后抽血并送
至实验室。结果会发送给您的医生。要了解如何解读这些检测结果，请阅读弗莱博士的《叶酸修复 》一书。
What does this have to do with MTHFR?
这与 MTHFR 有什么关系?
Not much. There is no direct link between CFD in autism and MTHFR.
不多。 自闭症中的 CFD 5 MTHFR 之间没有直接联系。
MTHFR is a single nucleotide polymorphism (SNP) that is found in 40-60% of the population. It can make
it harder for the body to use folate. However, the treatment for MTHFR is typically a low dose of 5MTHF
(methylfolate), methyl B12, and B6. (These are typically the first things prescribed by a functional
medicine doctor for autism.)
MTHER 是一种单核音酸多态性 ( SNP )，在 40-60% 的人群中存在。它会使身体更难利用叶酸。然而，MTHFR
治疗通常是低剂量的 5MTHF (FASS RR) 、甲基维生素 B12 和维生素 B6。 (这些通常是功能医学医生为自闭
症患者开出的首选药物。)
By contrast, Cerebral Folate Deficiency (CFD) can result in a severe folate deficiency in the brain, and it is
caused by autoimmunity, mitochondrial dysfunction, or specific genetic abnormalities. It requires a much
higher dose of folinic acid to flood the brain with folate.
相比之下，脑叶酸缺乏症 (CFD) 会导致大脑严重叶酸缺乏，其病因包括自身免疫、线粒体功能障碍或特定基因异
常。这种疾病需要更高剂量的亚叶酸才能使大脑充满叶酸。
My kid is negative on a FRAT (Folate Receptor
Autoantibody Test). Can they still benefit from
Leucovorin and/or 5MTHF?
我的孩子叶酸受体自身抗体检测 (FRAT) 结果为阴性。他
还能从亚叶酸钙和/或 SMTHF 治疗中获益吗?
Possibly. It is possible to have severe Cerebral Folate Deficiency and no folate receptor autoantibodies
because of mitochondrial dysfunction or genetics.
What is the difference between Leucovorin and
5MTHF (methylfolate)?
亚叶酸钙和 SMTHF (甲基叶酸) 有什么区别?
5MTHF (Methylfolate) is a bit different than Leucovorin, which is high-dose folinic acid.
5MTHF (FSH) 与高剂量亚叶酸甲酯略有不同。
5MTHF is the most bioavailable form of folate, and at least half of Leucovorin is converted to 5MTHF in
the gut. However, it is unknown if SMTHF can treat CFD like Leucovorin because studies have not been
done. But we do know that some kids tolerate one over the other, so if Leucovorin doesn’t work, it may
be worth exploring SMTHF.
SMTHF 是生物利用度最高的叶屋形式，至少一半的亚叶琶钙在肠道中转化为 5MTHF。然而，由于尚未进行相关
研究，5MTHF 是否能像亚叶屋钙一样治疗 CFD 尚不清楚。但我们知道，有些孩子对其中一种药物的耐受性优于
另一种，因此，如果亚叶酸钙无效，或许值得兰试 5SMTHF 。
Are there side effects to Leucovorin?
亚叶酸外有副作用吗?
There may be. It is a B vitamin, and B vitamins are activating. Just because your child may be hyperactive
in the beginning, does not mean that they do not need folate in the brain. Talk to your doctor about
introducing it slowly. Your child may need time to adjust to it.
有可能。它是一种 B 族维生素，而 B 族维生素具有激活作用。即使你的孩子一开始可能过度活跃，也不意味着他
们的大脑不需要叶酸。请咨询你的医生，慢慢地开始补充。你的孩子可能需要时间来适应。
Work with your doctor if your child is not tolerating it. Some strategies may help. You may need to lower
the dose while your child adjusts, try compounding it, trial SMTHF instead, or introduce calming
supplements.
如果您的孩子无法耐受，请咨询医生。一些策略可能会有所帮助。您可能需要在孩子适应期间降低剂量，兰试复
合用药，兰试使用5MTHF 蔡代，或者引入镇静补充剂。
Are there supplements needed in conjunction
with Leucovorin?
SE ro eS OTA ART EF?
Since Leucovorin is B9 and B vitamins give energy, most functional medicine doctors start by introducing
a combination of calming supplements before Leucovorin. Examples include magnesium glycinate,
folate into the cell. Examples include prescription LevoCarnitine, f
此外，你可能需要讨论引入一些有助于叶酸进入细胞的线粒体补充剂 。例如处方左旋肉碱、 维生素 B12 、核黄
素和维生素 B6。
Does my child need to be on a special diet while
on Leucovorin?
我的孩子服用亚叶酸钙期间需要特殊饮食吗?
Yes! Your child needs to be dairy-free while treating Cerebral Folate Deficiency with Leucovorin
because dairy blocks folate receptors. If your child is still consuming dairy, they may have a harder time
getting folate to the brain.
是的! AVF EEA | AEST oe | RS EA SAL loa, AAFLtlaaSthWil| RS, WORRY
孩子仍在食用乳制品，他们可能会更难将叶酸输送到大脑。
Can leucovorin help my teen or adult diagnosed
with autism?
WNT ER Sects ISS BAS Sake AS?
Leucovorin can help anyone who has low folate in their brain, no matter their age.
FOC), SUSAR AAS BM BS SAA.
Conclusion 结论
There have been numerous questions about Leucovorin for autism due to the media coverage. We hope
that this information is helpful. For additional information about Cerebral Folate Deficiency, please see
the TACA article here. If you are a parent of a person diagnosed with autism, you are welcome to join the
) and the thousands of parents treating their children with Leucovorin.
由于媒体报道，人们对使用亚叶酸钙治疗自闭症产生了许多疑问。我们希望这些信息对您有所帮助。如需了解更
多关于脑叶酸缺乏症的信息，请参阅此处的 TACA 文章 。如果您是自闭症患者的家长，欢迎加入 TACA 的
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